Expression of TMPRSS4 in patients with salivary adenoid cystic carcinoma: correlation with clinicopathological features and prognosis

Although there is growing evidence supporting the hypothesis that TMPRSS4 is linked with cancer susceptibility, the precise role of TMPRSS4 expression in salivary adenoid cystic carcinoma (SACC) is still unknown. The aim of this study was to examine TMPRSS4 expression in SACC and determine its assoc...

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Published in:Medical oncology (Northwood, London, England) London, England), 2013-12, Vol.30 (4), p.749-749, Article 749
Main Authors: Dai, Wei, Zhou, Qing, Xu, Zhongfei, Zhang, Enjiao
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Adenoid Cystic - genetics
Carcinoma, Adenoid Cystic - mortality
Carcinoma, Adenoid Cystic - pathology
Disease-Free Survival
Female
Hematology
Humans
Internal Medicine
Lymphatic Metastasis - genetics
Lymphatic Metastasis - pathology
Male
Medicine
Medicine & Public Health
Membrane Proteins - genetics
Middle Aged
Oncology
Original Paper
Pathology
Prognosis
Retrospective Studies
Salivary Gland Neoplasms - genetics
Salivary Gland Neoplasms - mortality
Salivary Gland Neoplasms - pathology
Salivary Glands - pathology
Serine Endopeptidases - genetics
Survival Analysis
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Summary:Although there is growing evidence supporting the hypothesis that TMPRSS4 is linked with cancer susceptibility, the precise role of TMPRSS4 expression in salivary adenoid cystic carcinoma (SACC) is still unknown. The aim of this study was to examine TMPRSS4 expression in SACC and determine its associations with clinicopathological features and survival. TMPRSS4 expression in 125 SACC tissue and adjacent non-cancerous tissues was analyzed by immunohistochemistry and Western blotting. In addition, the correlation of TMPRSS4 expression with clinicopathological variables was evaluated. The prognostic value of TMPRSS4 for overall survival (OS) and disease-free survival (DFS) was determined by Kaplan–Meier estimates, and the significance of differences between curves was evaluated by the log-rank test. We found that high TMPRSS4 expression was predominantly observed in SACC tissues, but not in the adjacent normal salivary gland tissues. High TMPRSS4 expression in SACC tissues was correlated significantly with tumor TNM stage ( P  = 0.016), lymph node metastasis ( P  = 0.002) and distant metastasis ( P  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0749-7