Age-Associated Changes in Sympathetic Neurons Containing Neurofilament 200 kDa during Chemical Deafferentation

Neurofilament with a molecular weight of 200 kDa is detected in the rat sympathetic ganglia since birth. The percentage of neurons containing this neurofilament decreases during the first 20 days of life. Just solitary neurofilament-positive neurons are detected in rats at the age of 180 and 360 day...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-06, Vol.155 (2), p.268-271
Main Authors: Porseva, V. V., Smirnova, V. P., Korzina, M. B., Emanuilov, A. I., Masliukov, P. M.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Biomedical and Life Sciences
Biomedicine
Capsaicin
Cell Biology
Internal Medicine
Laboratory Medicine
Male
Nerve Degeneration - chemically induced
Nerve Degeneration - physiopathology
Neurofilament Proteins - metabolism
Neurons
Pathology
Rats
Rats, Wistar
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurofilament with a molecular weight of 200 kDa is detected in the rat sympathetic ganglia since birth. The percentage of neurons containing this neurofilament decreases during the first 20 days of life. Just solitary neurofilament-positive neurons are detected in rats at the age of 180 and 360 days. Chemical deafferentation by capsaicin, used as a model of age-associated neuron degeneration, leads to a significant reduction of the level of neurofilament-200-imminopositive neurons in comparison with the control starting from day 10 of life. Presumably, part of the sympathetic ganglionic neurons are capsaicin-positive and their function is afferent.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2129-x