Tonic Pain Response during Inflammation and Stress-Induced Corticosterone Variations in Prenatally Stressed Infant Rats: Effects of Maternal Buspirone Injected during Pregnancy

We studied the effects of injections of 5-HT 1A -agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. During the period of the hypothalamic–pituitary–adrenal system hyporeactivity, th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-06, Vol.155 (2), p.194-196
Main Authors: Butkevich, I. P., Mikhailenko, V. A., Makukhina, G. V., Bagaeva, T. R., Stolyarova, Yu. A.
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Buspirone - pharmacology
Buspirone hydrochloride
Cell Biology
Corticosterone
Corticosterone - blood
Female
Formaldehyde
Inflammation - metabolism
Internal Medicine
Laboratory Medicine
Nociceptors - drug effects
Nociceptors - metabolism
Pain - drug therapy
Pain Measurement
Pathology
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Serotonin 5-HT1 Receptor Agonists - pharmacology
Steroids
Stress, Psychological
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Summary:We studied the effects of injections of 5-HT 1A -agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. During the period of the hypothalamic–pituitary–adrenal system hyporeactivity, the pain response in the formalin test was associated with stress-related corticosterone variations. Maternal buspirone normalized the pain reaction in prenatally stressed rats during all periods of the formalin test and modified the dynamics of the corticosterone response. In 1 day after the formalin test, the basal level of this hormone in blood plasma remained increased. Maternal buspirone increased the resistance of the nociceptive and stresssystems to inflammatory-induced pain response in prenatally stressed rats.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2110-8