Myxoid liposarcoma with cartilaginous differentiation: A case study with fish analysis and review of the literature

Cartilaginous differentiation is rarely encountered in myxoid liposarcomas. To date, a small number of such cases have been described, and molecular or cytogenetic analysis was performed only in few of them. In the present study, we describe a primary myxoid liposarcoma with cartilaginous differenti...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2013-10, Vol.209 (10), p.666-669
Main Authors: G.Ioannou, Maria, Kouvaras, Evangelos, Papamichali, Rodoula, Karachalios, Theophilos, Koukoulis, George
Format: Article
Language:English
Subjects:
Adult
Cartilage - pathology
Cartilaginous
Cell Differentiation
Fluorescence in situ hybridization
Humans
In Situ Hybridization, Fluorescence
Liposarcoma, Myxoid - genetics
Liposarcoma, Myxoid - pathology
Male
Myxoid liposarcoma
Oncogene Proteins, Fusion - genetics
Pathology
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Thigh - pathology
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Summary:Cartilaginous differentiation is rarely encountered in myxoid liposarcomas. To date, a small number of such cases have been described, and molecular or cytogenetic analysis was performed only in few of them. In the present study, we describe a primary myxoid liposarcoma with cartilaginous differentiation which arised in the left thigh of a 37-year-old man. Miscroscopically, the tumor consisted of areas with typical myxoid liposarcoma morphology and areas of sharply demarcated hyaline cartilage nodules. Here, we present the results of Fluorescence In Situ Hybridization (FISH) analysis that revealed the presence of FUS and DDIT3 gene rearrangements in both the liposarcomatous and cartilaginous components of the tumor. These findings confirm the neoplastic nature of the cartilage component in this rare tumor.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2013.06.010