Effects of Nanodispersed Iron on the Morphofunctional Parameters of the Blood System

The effects of nanodispersed iron forms on the morphology and function of the blood system were studied. Maghemite and lepidocrocite caused a leukocytic shift towards segmented neutrophil forms, reduction of lymphocyte rigidity, and stimulated their compactization. In addition, the counts of small h...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-08, Vol.155 (4), p.488-490
Main Authors: Skorkina, M. Yu, Vezentsev, A. I., Fedorova, M. Z., Simonov, V. V., Kanev, I. L.
Format: Article
Language:English
Subjects:
Animals
Animals, Outbred Strains
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Shape - drug effects
Erythrocyte Count
Erythrocytes - drug effects
Erythrocytes - physiology
Ferric Compounds - toxicity
Internal Medicine
Iron oxides
Laboratory Medicine
Leukocyte Count
Male
Nanoparticles - toxicity
Nanotechnologies
Nanotechnology
Neutrophils - drug effects
Neutrophils - physiology
Pathology
Rats
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Summary:The effects of nanodispersed iron forms on the morphology and function of the blood system were studied. Maghemite and lepidocrocite caused a leukocytic shift towards segmented neutrophil forms, reduction of lymphocyte rigidity, and stimulated their compactization. In addition, the counts of small hyperchromatic erythrocytes with high rigidity increased in the blood flow. The results indicated that a single dose of nanodispersed iron-containing drugs improved the blood respiratory function and its microrheology.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2185-2