Antioxidant Properties of Pyrrolobenzimidazole Derivative RU-792: Experimental Study

We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical p...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-08, Vol.155 (4), p.461-463
Main Authors: Kosolapov, V. A., Eltsova, L. V., Spasov, A. A., Anisimova, V. A.
Format: Article
Language:English
Subjects:
Antioxidants
Benzimidazoles - chemistry
Benzothiazoles - chemistry
Biomedical and Life Sciences
Biomedicine
Biphenyl Compounds - chemistry
Cell Biology
Chromans - chemistry
Free Radical Scavengers - chemistry
Free Radicals - chemistry
Internal Medicine
Kinetics
Laboratory Medicine
Lipid Peroxidation
Lipids
Luminol
Oxidation-Reduction
Pathology
Picrates - chemistry
Pyrroles - chemistry
Sulfonic Acids - chemistry
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Summary:We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe 2+ -induced chemiluminescence of lipids with 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2178-1