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TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress
•TNFR2 is localized at the cell surface of oligodendrocyte progenitor cells.•TNFR2 protects oligodendrocyte progenitor cells from oxidative stress.•TNFR2 induces the upregulation of cell survival genes. The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a...
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Published in: | Biochemical and biophysical research communications 2013-10, Vol.440 (2), p.336-341 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •TNFR2 is localized at the cell surface of oligodendrocyte progenitor cells.•TNFR2 protects oligodendrocyte progenitor cells from oxidative stress.•TNFR2 induces the upregulation of cell survival genes.
The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells. Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby providing a potential mechanism for the neuroprotective role of TNFR2 in oligodendrocyte progenitor cells. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/j.bbrc.2013.09.083 |