Re-evaluation of common paradigms regarding the clinical appearance of oral mucosal malignancies

Purpose To evaluate the clinical appearance and rate of ulceration of oral mucosal malignancies, and to investigate the accuracy of clinical provisional diagnoses. Methods A 10‐year retrospective analysis, which included diagnostic biopsies of malignant tumors of the oral mucosa. The clinical provis...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2013-10, Vol.42 (9), p.670-675
Main Authors: Allon, Irit, Allon, Dror M., Gal, Gavriel, Anavi, Yakir, Chaushu, Gavriel, Kaplan, Ilana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
benign
Biological and medical sciences
Biopsy - methods
Carcinoma - pathology
Carcinoma in Situ - pathology
Carcinoma, Mucoepidermoid - pathology
Carcinoma, Squamous Cell - pathology
Carcinoma, Verrucous - pathology
Child
Dentistry
Diagnosis, Differential
Female
Gingival Neoplasms - pathology
Humans
indurate ulcer
Lymphoma, Large B-Cell, Diffuse - pathology
Male
malignant
Medical sciences
Middle Aged
Mouth Neoplasms - pathology
Mouth Neoplasms - secondary
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
non-ulcerated mass
Oral Ulcer - pathology
Otorhinolaryngology. Stomatology
Retrospective Studies
Salivary Gland Neoplasms - pathology
Tongue Neoplasms - pathology
Tumors
ulcerated mass
Young Adult
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Summary:Purpose To evaluate the clinical appearance and rate of ulceration of oral mucosal malignancies, and to investigate the accuracy of clinical provisional diagnoses. Methods A 10‐year retrospective analysis, which included diagnostic biopsies of malignant tumors of the oral mucosa. The clinical provisional diagnoses were compared with final diagnoses. Results Two hundred and twenty‐seven oral mucosal malignant tumors were included. Squamous cell carcinoma and its variants accounted for the majority (78%) of all malignant tumors. The most common clinical presentations were non‐ulcerated (59.7%) and ulcerated masses (20.4%). Only 11.9% presented as indurate ulcers. The highest ulceration rate of all malignancies was recorded for SCC, with only about half of SCC and its variants ulcerated at the time of biopsy. 31.1% of all malignancies were not clinically suspected to be malignant and did not even include a request to rule out malignancy. There was a better agreement between the clinical provisional diagnoses and microscopic diagnoses in the SCC group than in other types of malignancy (P 
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12075