Effects of risperidone on the acquisition and reinstatement of the conditioned place preference induced by MDMA

Highlights • Risperidone impairs the acquisition of MDMA-induced CPP in mice. • Risperidone does not affect priming-induced reinstatement of MDMA-induced CPP in mice. • Dopamine has an important role in the acquisition of MDMA-conditioned reward.

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Bibliographic Details
Published in:Brain research bulletin 2013-09, Vol.98, p.36-43
Main Authors: Roger-Sánchez, C, Rodríguez-Arias, M, Miñarro, J, Aguilar, M.A
Format: Article
Language:English
Subjects:
Adolescence
Age Factors
Animals
Animals, Newborn
Antipsychotic Agents - pharmacology
Conditioned place preference
Conditioning (Psychology) - drug effects
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Dopamine Plasma Membrane Transport Proteins - metabolism
Dose-Response Relationship, Drug
Drug Interactions
Hallucinogens - pharmacology
Male
MDMA
Mice
N-Methyl-3,4-methylenedioxyamphetamine - pharmacology
Neurology
Reward
Risperidone
Risperidone - pharmacology
Serotonin Plasma Membrane Transport Proteins - metabolism
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Summary:Highlights • Risperidone impairs the acquisition of MDMA-induced CPP in mice. • Risperidone does not affect priming-induced reinstatement of MDMA-induced CPP in mice. • Dopamine has an important role in the acquisition of MDMA-conditioned reward.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2013.07.009