Chromosome instability in mutagen sensitive mutants of Neurospora

Four mutagen sensitive mutants of Neurospora (mus-7, mus-9, mus-11, and mei-2) are shown to increase mitotic chromosome instability in the duplication test developed by Newmeyer. Three other mutagen-sensitive mutants (upr-1, mus-8, and mus-10) do not increase chromosome instability. Previously three...

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Bibliographic Details
Published in:Current genetics 1986, Vol.10 (5), p.381-387
Main Author: Schroeder, A.L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Division - drug effects
chromosomes
Chromosomes - drug effects
Fundamental and applied biological sciences. Psychology
genes
hydroxyurea
Hydroxyurea - pharmacology
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Mutagens - pharmacology
mutants
Neurospora
Neurospora - drug effects
Neurospora - genetics
nucleotides
stability
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Summary:Four mutagen sensitive mutants of Neurospora (mus-7, mus-9, mus-11, and mei-2) are shown to increase mitotic chromosome instability in the duplication test developed by Newmeyer. Three other mutagen-sensitive mutants (upr-1, mus-8, and mus-10) do not increase chromosome instability. Previously three mutagen-sensitive mutants (uvs-3, uvs-6, and mei-3) were also shown to increase chromosome instability. The growth of all seven mutants that increase chromosome instability, is shown here to be more sensitive to hydroxyurea than that of wild type. Hydroxyurea, a compound which inhibits the enzyme ribonucleotide diphosphate reductase, is also shown to increase chromosome instability in the absence of any mutagen-sensitive mutation. These seven mutations are known to represent seven different genes in two epistasis groups. They have been shown previously to have four other properties in common: meiotic defects and sensitivity to gamma-rays, methyl methane sulfonate and the amino acid histidine. Their shared properties lead to the prediction here that all have reduced or altered deoxyribonucleotide pools.
ISSN:0172-8083
1432-0983
DOI:10.1007/BF00418410