Signaling effects of substrate stimulation of nNOS in rat soleus after eccentric exercise

A study investigated the signaling effects of substrate stimulation of nNos in rat soleus after eccentric exercise. The administration of L arginine prior to eccentric exercise, preventing the degradation of cytoskeletal proteins in m. soleus, leads to an increase in the working capacity of rats and...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2013-09, Vol.452 (1), p.271-275
Main Authors: Lomonosova, Y. N., Shenkman, B. S., Nemirovskaya, T. L.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Cytoskeleton
Exercise
Gene expression
Life Sciences
Male
Muscle, Skeletal - enzymology
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Nitric oxide
Nitric Oxide Synthase Type I - genetics
Nitric Oxide Synthase Type I - metabolism
Physical Exertion
Proteins
Rats
Rats, Wistar
Ribonucleic acid
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
Substrates
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Summary:A study investigated the signaling effects of substrate stimulation of nNos in rat soleus after eccentric exercise. The administration of L arginine prior to eccentric exercise, preventing the degradation of cytoskeletal proteins in m. soleus, leads to an increase in the working capacity of rats and a decrease in the calpain mRNA expression in it. Single eccentric exercise leads to a decrease in the levels of expression of E3 ligases MAFbx and MuRF 1 in the muscle. nNOS is involved in the regulation of protein metabolism during eccentric exercise.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672913050177