Analysis of phyllodes tumor recurrence according to the histologic grade

Local recurrence of phyllodes tumor (PT) of the breast is an adverse outcome that can result in sarcomatous degeneration. The aim of this study was to investigate the histologic and surgical factors associated with local recurrence. A total of 193 PT cases were studied: 145 (75.1 %) benign cases, 33...

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Bibliographic Details
Published in:Breast cancer research and treatment 2013-10, Vol.141 (3), p.353-363
Main Authors: Kim, Sewha, Kim, Ji-Ye, Kim, Do Hee, Jung, Woo Hee, Koo, Ja Seung
Format: Article
Language:English
Subjects:
Adult
Analysis
Biological and medical sciences
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Breasts
Cancer research
Cancer therapies
Classification
Disease-Free Survival
Diseases
Female
Gynecology. Andrology. Obstetrics
Histology
Humans
Kaplan-Meier Estimate
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local - prevention & control
Nuclear radiation
Oncology
Phyllodes Tumor - mortality
Phyllodes Tumor - pathology
Phyllodes Tumor - surgery
Preclinical Study
Relapse
Risk factors
Surgery
Tumors
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Summary:Local recurrence of phyllodes tumor (PT) of the breast is an adverse outcome that can result in sarcomatous degeneration. The aim of this study was to investigate the histologic and surgical factors associated with local recurrence. A total of 193 PT cases were studied: 145 (75.1 %) benign cases, 33 (17.1 %) borderline cases, and 15 (7.8 %) malignant cases. Stratifying our analysis according to histologic grade, we investigated the relationship between disease-free survival (DFS) and both histologic and surgical factors, including histologic grade, stromal cellularity, stromal atypia, stromal mitosis, stromal overgrowth, tumor margin, type of surgical procedure (local excision, wide excision, and mastectomy), surgical margin status, and radiation therapy. In the case of benign PT, all patients with local recurrences (3.4 %) had been treated with local excision, and all recurrent tumors were also benign. The local recurrence rate for locally excised benign PTs was not associated with surgical margin status or radiation therapy. In the case of borderline PT, local excision was associated with an increased local recurrence rate ( P  = 0.046). In malignant PT, small tumor size (≤4.0 cm) was associated with an increased local recurrence rate ( P  = 0.041). Univariate analyses indicated that surgical procedure (mastectomy 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-013-2684-x