Ferritin in the antiphospholipid syndrome and its catastrophic variant (cAPS)

Background Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link betwe...

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Bibliographic Details
Published in:Lupus 2013-11, Vol.22 (13), p.1327-1335
Main Authors: Agmon-Levin, N, Rosário, C, Katz, B-S Porat, Zandman-Goddard, G, Meroni, P, Cervera, R, Stojanovich, L, Blank, M, Pierangeli, SS, Praprotnik, S, Meis, E de, Seguro, L Parente, Ruffatti, A, Pengo, V, Tincani, A, Doria, A, Shoenfeld, Y
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Antiphospholipid - blood
Antibodies, Protozoan - blood
Antibodies, Viral - blood
Antiphospholipid Syndrome - blood
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - diagnosis
Autoimmune diseases
Biomarkers - blood
Case-Control Studies
Catastrophic Illness
Disease
Female
Ferritins - blood
Hematology
Humans
Lupus
Male
Medicine
Middle Aged
Pathogenesis
Prognosis
Rheumatology
Serologic Tests
Serology
Up-Regulation
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Summary:Background Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the antiphospholipid syndrome (APS) has been rarely explored. Therefore, in the current study we evaluated ferritin levels and their correlation to clinical and serological manifestations in patients with APS. We further analyzed ferritin levels among patients with the catastrophic variant of APS (cAPS). Methods Ferritin levels were determined in serum samples of 176 APS patients and 98 matched healthy controls according to age and sex (LIAISON, DiaSorin, Italy). APS samples were further analyzed for antiphospholipid (anti-cardiolipin, anti- beta-2-glycoprotein, lupus anticoagulant) and anti-infectious antibodies (CMV, EBV, rubella, toxoplasma, HBV) (LIAISON, DiaSorin, Italy). Clinical, serological and demographic manifestations were recorded. An additional analysis of ferritin levels among 14 patients with cAPS was performed. Results Hyperferritinemia was present in 9% vs. 0% of APS patients and controls, respectively (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203313504633