Aquatic toxicity evaluated using human and monkey cell culture assays

The effect of model aquatic pollutants (cadmium, copper, zinc) on the growth of human established cell line KB, and primary African green monkey kidney (AGMK) cell cultures was determined. The ID50's (concentrations causing 50 per cent reduction in cell number after 72 h incubation) for cadmium...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1986-04, Vol.36 (4), p.523-526
Main Author: MOCHIDA, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Cells, Cultured
Cercopithecus aethiops
Environmental pollutants toxicology
Humans
Japan
KB Cells - cytology
Kidney - cytology
Medical sciences
Metals - toxicity
Toxicology
Water
Water Pollutants - toxicity
Water Pollutants, Chemical - toxicity
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Summary:The effect of model aquatic pollutants (cadmium, copper, zinc) on the growth of human established cell line KB, and primary African green monkey kidney (AGMK) cell cultures was determined. The ID50's (concentrations causing 50 per cent reduction in cell number after 72 h incubation) for cadmium, copper, and zinc were 5.5, 150.0, and 100.0 uM respectively in KB cells, and 3.0, 100.0, and 82.0 uM respectively in AGMK cells. The river water and groundwater used in these experiments was not toxic to either cell culture. These results indicated that the cell culture assay was more sensitive than the algal bioassay, and provided a simple, rapid, quantitative method of determining aquatic toxicity.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01623546