GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion

Highlights • We showed the expression pattern of GPER in mouse differentiating adipocyte 3T3-L1. • Activation of GPER had inhibitory effect on adipocyte 3T3-L1 differentiation. • The adipogenic inhibition was exerted through perturbation of mitotic clonal expansion.

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Bibliographic Details
Published in:General and comparative endocrinology 2013-11, Vol.193, p.19-26
Main Authors: Zhu, Pei, Yuen, Jacky M.L, Sham, Kathy W.Y, Cheng, Christopher H.K
Format: Article
Language:English
Subjects:
3T3-L1
3T3-L1 Cells
Adipogenesis
Adipogenesis - drug effects
agonists
Animals
Blotting, Western
cell cycle
Cell Cycle - drug effects
Cell Survival - drug effects
cyclin-dependent kinase
Endocrinology & Metabolism
estradiol
Estradiol - pharmacology
Estrogen
estrogen receptors
Estrogens - pharmacology
GPER
Mice
Mitotic clonal expansion
phosphorylation
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - metabolism
Reverse Transcriptase Polymerase Chain Reaction
serine
small interfering RNA
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Description
Summary:Highlights • We showed the expression pattern of GPER in mouse differentiating adipocyte 3T3-L1. • Activation of GPER had inhibitory effect on adipocyte 3T3-L1 differentiation. • The adipogenic inhibition was exerted through perturbation of mitotic clonal expansion.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.07.004