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GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion
Highlights • We showed the expression pattern of GPER in mouse differentiating adipocyte 3T3-L1. • Activation of GPER had inhibitory effect on adipocyte 3T3-L1 differentiation. • The adipogenic inhibition was exerted through perturbation of mitotic clonal expansion.
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| Published in: | General and comparative endocrinology 2013-11, Vol.193, p.19-26 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c504t-4fc007083e989fea296a66a9e3b4284ce17d3b1e898af12c1b7f3ededac9f91d3 |
| container_end_page | 26 |
| container_issue | |
| container_start_page | 19 |
| container_title | General and comparative endocrinology |
| container_volume | 193 |
| creator | Zhu, Pei Yuen, Jacky M.L Sham, Kathy W.Y Cheng, Christopher H.K |
| description | Highlights • We showed the expression pattern of GPER in mouse differentiating adipocyte 3T3-L1. • Activation of GPER had inhibitory effect on adipocyte 3T3-L1 differentiation. • The adipogenic inhibition was exerted through perturbation of mitotic clonal expansion. |
| doi_str_mv | 10.1016/j.ygcen.2013.07.004 |
| format | article |
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| ispartof | General and comparative endocrinology, 2013-11, Vol.193, p.19-26 |
| issn | 0016-6480 1095-6840 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | 3T3-L1 3T3-L1 Cells Adipogenesis Adipogenesis - drug effects agonists Animals Blotting, Western cell cycle Cell Cycle - drug effects Cell Survival - drug effects cyclin-dependent kinase Endocrinology & Metabolism estradiol Estradiol - pharmacology Estrogen estrogen receptors Estrogens - pharmacology GPER Mice Mitotic clonal expansion phosphorylation Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction serine small interfering RNA |
| title | GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion |
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