Diffuse gastroduodenitis associated with ulcerative colitis: Treatment by infliximab

Diffuse gastroduodenitis resembling ulcerative colitis in respect to macro‐ and microscopic findings occurs in ulcerative colitis, although it is rare. Reports of gastroduodenitis associated with ulcerative colitis treated with infliximab are rare. A 58‐year‐old man had tarry stool in March 2011. He...

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Bibliographic Details
Published in:Digestive endoscopy 2013-11, Vol.25 (6), p.622-625
Main Authors: Chiba, Mitsuro, Ono, Iwao, Wakamatsu, Hideki, Wada, Isao, Suzuki, Katsuhiko
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - therapeutic use
Biopsy
Colitis, Ulcerative - complications
complication
Duodenal Ulcer - complications
Duodenal Ulcer - diagnosis
duodenitis
Duodenitis - diet therapy
Duodenitis - drug therapy
Duodenitis - etiology
Endoscopy, Digestive System
Gastritis - drug therapy
Gastritis - etiology
Gastrointestinal Agents - therapeutic use
Humans
Infliximab
Male
Middle Aged
Remission Induction
ulcerative colitis
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Summary:Diffuse gastroduodenitis resembling ulcerative colitis in respect to macro‐ and microscopic findings occurs in ulcerative colitis, although it is rare. Reports of gastroduodenitis associated with ulcerative colitis treated with infliximab are rare. A 58‐year‐old man had tarry stool in March 2011. He had a history of ulcerative colitis that was diagnosed in 1984. He underwent subtotal colectomy in 1991. Endoscopy and radiography revealed diffuse friable mucosa throughout the duodenum and an ulcer in the middle of the descending portion, resulting in a narrow portion.In the stomach, numerous small aphthae were observed in the antrum. Biopsy specimens of the duodenum and antrum showed marked inflammatory cell infiltration in both areas and cryptitis in the duodenum. Standard induction therapy of infliximab was started in April. The ulcer in the descending portion became a scar without diffuse mucosal friability in September 2011.
ISSN:0915-5635
1443-1661
DOI:10.1111/j.1443-1661.2012.01398.x