Diffuse gastroduodenitis associated with ulcerative colitis: Treatment by infliximab

• Published in: Digestive endoscopy 2013-11, Vol.25 (6), p.622-625
• Main Authors: Chiba, Mitsuro, Ono, Iwao, Wakamatsu, Hideki, Wada, Isao, Suzuki, Katsuhiko
• Format: Article
• Language: English
• Subjects: Antibodies, Monoclonal - therapeutic use; Biopsy; Colitis, Ulcerative - complications; complication; Duodenal Ulcer - complications; Duodenal Ulcer - diagnosis; duodenitis; Duodenitis - diet therapy; Duodenitis - drug therapy; Duodenitis - etiology; Endoscopy, Digestive System; Gastritis - drug therapy; Gastritis - etiology; Gastrointestinal Agents - therapeutic use; Humans; Infliximab; Male; Middle Aged; Remission Induction; ulcerative colitis
• ISSN: 0915-5635; 1443-1661
• DOI: 10.1111/j.1443-1661.2012.01398.x

Diffuse gastroduodenitis resembling ulcerative colitis in respect to macro‐ and microscopic findings occurs in ulcerative colitis, although it is rare. Reports of gastroduodenitis associated with ulcerative colitis treated with infliximab are rare. A 58‐year‐old man had tarry stool in March 2011. He had a history of ulcerative colitis that was diagnosed in 1984. He underwent subtotal colectomy in 1991. Endoscopy and radiography revealed diffuse friable mucosa throughout the duodenum and an ulcer in the middle of the descending portion, resulting in a narrow portion.In the stomach, numerous small aphthae were observed in the antrum. Biopsy specimens of the duodenum and antrum showed marked inflammatory cell infiltration in both areas and cryptitis in the duodenum. Standard induction therapy of infliximab was started in April. The ulcer in the descending portion became a scar without diffuse mucosal friability in September 2011.