Polymorphic AAAG Repeat Length in Estrogen-Related Receptor Gamma (ERRγ) and Risk of Breast Cancer in Iranian Women

Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n...

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Bibliographic Details
Published in:Cancer investigation 2013-11, Vol.31 (9), p.600-603
Main Authors: Karimi, Padideh, Hematti, Simin, Safari, Foruzan, Tavassoli, Manoochehr
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Breast cancer
Breast Neoplasms - ethnology
Breast Neoplasms - genetics
Case-Control Studies
Chi-Square Distribution
ERRγ
Female
Gene Frequency
Genetic Predisposition to Disease
Gynecology. Andrology. Obstetrics
Humans
Introns
Iran - epidemiology
Mammary gland diseases
Medical sciences
Microsatellite
Microsatellite Repeats
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Odds Ratio
Pharmacology. Drug treatments
Polymorphism
Polymorphism, Genetic
Receptors, Estrogen - genetics
Risk Factors
Tumors
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Summary:Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ERRγ gene, a case-control study of 200 breast cancer patients and 200 controls was performed in Iranian women. Our results demonstrate that women with short AAAG repeat are at higher risk of breast cancer (OR 7). This result suggests a possible involvement of polymorphic AAAG repeat of ERRγ gene in regulating its expression.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2013.845672