Signal transducers and activators of transcription 3 function in lung cancer

Constitutively activation of signal transducers and activators of transcription 3 (STAT3) proteins are involved in multiple aberrant signaling pathway-oncogenic pathways, including pathways regulating tumor cell survival. STAT3 is one of the second messengers in the Janus activated family kinases/ST...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2013-09, Vol.9 (5), p.67-73
Main Authors: Li, Chun-Jie, Li, Yue-Chuan, Zhang, Dong-Rui, Pan, Jian-Hui
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Breast cancer
Cancer
Cancer cells
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Care and treatment
Cell Proliferation
Cellular signal transduction
Competition
Development and progression
Disease Progression
Gene Expression Regulation, Neoplastic
Genes
Humans
Kinases
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Observations
Properties
Signal Transduction
STAT proteins
STAT3 Transcription Factor - physiology
Tumors
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Summary:Constitutively activation of signal transducers and activators of transcription 3 (STAT3) proteins are involved in multiple aberrant signaling pathway-oncogenic pathways, including pathways regulating tumor cell survival. STAT3 is one of the second messengers in the Janus activated family kinases/STAT signaling pathway and is regulated by many different factors involving tumorigenesis. Given that the activation of STAT3 is observed in nearly 50% of Lung cancers and more and more researches regarding STAT3 in tumors, here in, we reviewed the contribution of STAT3 to lung cancer growth and progression and then the context in which positive and negative regulation of STAT activation leading to cell competition provides a mechanism for therapeutic intervention for specific cancers is discussed.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.119100