Contrast-enhanced transrectal ultrasonography: Measurement of prostate cancer tumor size and correlation with radical prostatectomy specimens

Objectives To determine the accuracy of contrast‐enhanced transrectal ultrasonography for tumor size measurements of hypoechoic prostate cancer foci located in the peripheral zone. Methods A total of 55 men scheduled for radical prostatectomy, with biopsy‐proven cancer in hypoechoic foci located in...

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Bibliographic Details
Published in:International journal of urology 2013-11, Vol.20 (11), p.1085-1091
Main Authors: Qi, Ting Yue, Chen, Ya Qing, Jiang, Jun, Zhu, Yun Kai, Yao, Xiao Hong, Qi, Jun
Format: Article
Language:English
Subjects:
Aged
contrast-enhanced ultrasonography
grayscale
Humans
Male
Middle Aged
Phospholipids
Prospective Studies
Prostate - pathology
prostate cancer
Prostatectomy
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
radical prostatectomy
Sulfur Hexafluoride
Ultrasonography
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Summary:Objectives To determine the accuracy of contrast‐enhanced transrectal ultrasonography for tumor size measurements of hypoechoic prostate cancer foci located in the peripheral zone. Methods A total of 55 men scheduled for radical prostatectomy, with biopsy‐proven cancer in hypoechoic foci located in the peripheral zone, were consecutively enrolled in the present prospective study. Each patient underwent grayscale ultrasound and contrast‐enhanced transrectal ultrasonography of the prostate according to a standardized protocol. The maximum tumor diameter on grayscale imaging and contrast‐enhanced transrectal ultrasonography was compared with that determined using histopathology. Results A mean underestimation was documented to be approximately 3.9 mm and 0.6 mm for grayscale and contrast‐enhanced transrectal ultrasonography imaging, respectively. Grayscale and contrast‐enhanced transrectal ultrasonography imaging underestimated measurements by 76.67% (46 of 60) and 48.33% (29 of 60), whereas overestimated measurements were 20% (12 of 60) and 26.67% (16 of 60), respectively. A strong correlation was observed between contrast‐enhanced transrectal ultrasonography and histopathological measurements (r = 0.91, P 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.12125