Development of a prediabetic state under chronic alcohol intoxication

We investigated the changes in key parameters of carbohydrate and lipid metabolism, which correspond to the clinical picture that accompanies the development of prediabetic condition on the background of chronic alcohol intoxication. From the analysis of glycemic curves obtained during the insulin-g...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2013, Vol.59 (4), p.33-39
Main Authors: Voĭtenko, V V, Konopel'niuk, V V, Savchuk, O M, Ostapchenko, L I
Format: Article
Language:eng ; ukr
Subjects:
Alcoholism - complications
Alcoholism - metabolism
Alcoholism - physiopathology
Animals
Animals, Outbred Strains
Biological Transport
Blood Glucose - metabolism
Brain - metabolism
Ethanol - administration & dosage
Female
Insulin - metabolism
Insulin Resistance
Male
Prediabetic State - complications
Prediabetic State - metabolism
Prediabetic State - physiopathology
Rats
Serotonin - blood
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Summary:We investigated the changes in key parameters of carbohydrate and lipid metabolism, which correspond to the clinical picture that accompanies the development of prediabetic condition on the background of chronic alcohol intoxication. From the analysis of glycemic curves obtained during the insulin-glucose test, a speed of glucose uptake by peripheral tissues increased at the 1st day (1.5 fold) and the third day (1.3 fold) of administration of alcohol solution. At the later periods, at 7 and 11 days of ethanol administration, a decreased rate of glucose uptake in animals with chronic alcohol intoxication was detected. We also detected an increased content of serotonin in the blood serum and a decreased (1.2 fold) serotonin content in rat brain during the whole period of development of chronic alcohol intoxication.
ISSN:2522-9028
2522-9036
DOI:10.15407/fz59.04.033