Dietary carbohydrate restriction improves insulin sensitivity, blood pressure, microvascular function, and cellular adhesion markers in individuals taking statins

Abstract Statins positively impact plasma low-density lipoprotein cholesterol, inflammation and vascular endothelial function (VEF). Carbohydrate restricted diets (CRD) improve atherogenic dyslipidemia, and similar to statins, have been shown to favorably affect markers of inflammation and VEF. No s...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2013-11, Vol.33 (11), p.905-912
Main Authors: Ballard, Kevin D, Quann, Erin E, Kupchak, Brian R, Volk, Brittanie M, Kawiecki, Diana M, Fernandez, Maria Luz, Seip, Richard L, Maresh, Carl M, Kraemer, William J, Volek, Jeff S
Format: Article
Language:English
Subjects:
adhesion
Aged
Biological and medical sciences
biomarkers
blood flow
Blood Pressure
carbohydrate intake
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
cell adhesion
cholesterol
compliance
diastolic blood pressure
Diet, Carbohydrate-Restricted
dietary carbohydrate
E-Selectin - blood
energy intake
Feeding. Feeding behavior
Flow mediated dilation
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Human
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
hyperlipidemia
Inflammation
insulin
Insulin - blood
Insulin Resistance
low density lipoprotein
Low-carbohydrate diets
Middle Aged
Regional Blood Flow - drug effects
therapeutics
triacylglycerols
Triglycerides - blood
Vascular Cell Adhesion Molecule-1 - blood
Vascular endothelial function
Vasodilation - drug effects
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract Statins positively impact plasma low-density lipoprotein cholesterol, inflammation and vascular endothelial function (VEF). Carbohydrate restricted diets (CRD) improve atherogenic dyslipidemia, and similar to statins, have been shown to favorably affect markers of inflammation and VEF. No studies have examined whether a CRD provides additional benefit beyond that achieved by habitual statin use. We hypothesized that a CRD (
ISSN:0271-5317
1879-0739
DOI:10.1016/j.nutres.2013.07.022