Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy

A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5-10 nm, length similar to 200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2013-01, Vol.4 (11), p.4168-4174
Main Authors: Mandal, Subhra, Eksteen-Akeroyd, Zaskia H., Jacobs, Monique J., Hammink, Roel, Koepf, Matthieu, Lambeck, Annechien J. A., van Hest, Jan C. M., Wilson, Christopher J., Blank, Kerstin, Figdor, Carl G., Rowan, Alan E.
Format: Article
Language:English
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Summary:A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5-10 nm, length similar to 200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated these highly controlled, semi-stiff polymers with T cell activating anti-CD3 antibodies and analyzed their application potential as simple synthetic mimics of dendritic cells (sDCs). Our sDCs do not only activate T cells at significantly lower concentrations than free antibodies or rigid sphere-like counterparts (PLGA particles) but also induce a more robust T cell response. Our novel design further yields sDCs that are biocompatible and non-toxic. The observed increased efficacy highlights the importance of architectural flexibility and multivalency for modulating T cell response and cellular function in general.
ISSN:2041-6520
2041-6539
DOI:10.1039/c3sc51399h