A Study on the Geophylogeny of Clinical and Environmental Vibrio cholerae in Kenya: e74829

Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya i...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-09, Vol.8 (9)
Main Authors: Kiiru, John, Mutreja, Ankur, Mohamed, Ahmed Abade, Kimani, Racheal W, Mwituria, Joyce, Sanaya, Robert Onsare, Muyodi, Jane, Revathi, Gunturu, Parkhill, Julian, Thomson, Nicholas
Format: Article
Language:English
Subjects:
Vibrio cholerae
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya isolated between 2005 and 2010. Some environmental and all clinical isolates mapped back onto wave three of the monophyletic seventh pandemic V. cholerae El Tor phylogeny but other environmental isolates were phylogenetically very distinct. Thus, the genomes of the Kenyan V. cholerae O1 El Tor isolates are clonally related to other El Tor V. cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently.
ISSN:1932-6203
DOI:10.1371/journal.pone.0074829