Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion

Summary Losses in 13q as a sole abnormality confer a good prognosis in chronic lymphocytic leukaemia (CLL). Nevertheless, its heterogeneity has been demonstrated and the clinical significance of biallelic 13q deletions remains controversial. We compared the clinico‐biological characteristics of a se...

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Published in:British journal of haematology 2013-10, Vol.163 (1), p.47-54
Main Authors: Puiggros, Anna, Delgado, Julio, Rodriguez‐Vicente, Ana, Collado, Rosa, Aventín, Anna, Luño, Elisa, Grau, Javier, Hernandez, José Ángel, Marugán, Isabel, Ardanaz, Maite, González, Teresa, Valiente, Alberto, Osma, Mar, Calasanz, Maria José, Sanzo, Carmen, Carrió, Ana, Ortega, Margarita, Santacruz, Rodrigo, Abrisqueta, Pau, Abella, Eugènia, Bosch, Francesc, Carbonell, Félix, Solé, Francesc, Hernández, Jesús Maria, Espinet, Blanca
Format: Article
Language:English
Subjects:
13q deletion
Adult
Aged
Aged, 80 and over
Alleles
biallelic
Biological and medical sciences
Cell survival
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 13
chronic lymphocytic leukaemia
Female
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Leukemia, Lymphocytic, Chronic, B-Cell - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
monoallelic
Prognosis
Retrospective Studies
Treatment Outcome
Tumors
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Summary:Summary Losses in 13q as a sole abnormality confer a good prognosis in chronic lymphocytic leukaemia (CLL). Nevertheless, its heterogeneity has been demonstrated and the clinical significance of biallelic 13q deletions remains controversial. We compared the clinico‐biological characteristics of a series of 627 patients harbouring isolated 13q deletions by fluorescence in situ hybridization (FISH), either monoallelic (13q × 1), biallelic (13q × 2), or the coexistence of both clones (13qM). The most frequent 13q deletion was 13q × 1 (82·1%), while 13q × 2 and 13qM represented 8·6% and 9·3% of patients respectively. The median percentage of altered nuclei significantly differed across groups: 55%, 72·5% and 80% in 13q × 1, 13q × 2 and 13qM (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12479