Using Oxidized Low-Density Lipoprotein Autoantibodies to Predict Restenosis after Balloon Angioplasty in Patients with Acute Myocardial Infarction: e74726

• Published in: PloS one 2013-10, Vol.8 (10)
• Main Authors: Huang, Ching-Hui, Chang, Chia-Chu, Huang, Ching-Shan, Kuo, Chen-Ling, Chen, Ching-Pei, Hsia, Chien-Hsun, Chang, Yung-Ming, Chen, Hung-Te, Feng, Chih-Chung, Lin, Lee-Shin
• Format: Article
• Language: English
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0074726

Objectives Oxidized low-density lipoproteins (oxLDL) and oxidized low-density lipoprotein autoantibodies (OLAB) have been detected in human plasma and atherosclerotic lesions. OLAB appear to play a role in the clearance of oxLDL from circulation. Higher levels of OLAB appear to be associated with a reduced risk of a wide range of cardiovascular diseases. We investigated the prognostic value of plasma oxLDL and OLAB in patients undergoing primary coronary balloon angioplasty for acute ST-elevation myocardial infarction (STEMI). Methods Plasma oxLDL and OLAB concentrations were measured in 56 patients with acute STEMI before primary angioplasty, and then 3 days, 7 days and 1 month after the acute event. Follow-up angiography was repeated 6 months later to detect the presence of restensosis (defined as >50% luminal diameter stenosis). The thrombolysis in myocardial infarction (TIMI) risk score was calculated to determine the relationship between OLAB/oxLDL ratio and TIMI risk scores. Results Of the 56 patients, 18 (31%) had angiographic evidence of restenosis. Plasma OLAB concentrations were significantly lower in the restenosis group before angioplasty (181 plus or minus 114 vs. 335 plus or minus 257 U/L, p = 0.003), and at day 3 (155 plus or minus 92 vs. 277 plus or minus 185 U/L, p