Fumonisin B1 and ochratoxin A nephrotoxicity in Japanese quail: an ultrastructural assessment

In the present study, fumonisin B 1 (200 ppm) and ochratoxin A (2 ppm) were fed alone and in combination to day old Japanese quail chicks for 21 days to evaluate renal ultrastructural changes. The severity and intensity of renal ultrastructural changes varied with the type of treatment, and predomin...

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Bibliographic Details
Published in:Comparative clinical pathology 2013-09, Vol.22 (5), p.835-843
Main Authors: Khan, Manzoor Ahmad, Asrani, R. K., Iqbal, Asif, Patil, R. D., Rottinghaus, G. E., Ledoux, D. R.
Format: Article
Language:English
Subjects:
Coturnix japonica
Endoplasmic reticulum
Hematology
Medicine
Medicine & Public Health
Oncology
Original Article
Pathology
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Summary:In the present study, fumonisin B 1 (200 ppm) and ochratoxin A (2 ppm) were fed alone and in combination to day old Japanese quail chicks for 21 days to evaluate renal ultrastructural changes. The severity and intensity of renal ultrastructural changes varied with the type of treatment, and predominant and consistent lesions were found in the proximal convoluted tubule (PCT) lining cells. Distortion and dilatation of cisternae of endoplasmic reticulum leading to the formation of vesicular and tubular structures was a consistent finding noticed in the fumonisin B 1 -fed group. Ochratoxin A treatment revealed characteristic changes in the epithelial brush border of PCTs with blunting and variable loss of microvilli. Reduced number of mitochondria with mitochondrial pleomorphism (round, oval, curved, elongated, dumbbell, banana, pear, and tennis racket) was almost a consistent finding noticed in the ochratoxin A treatment group. Ultrastructural changes in the combination fed group were almost similar to those noticed in the individual treatment groups but were of a higher intensity. Or in other words, we can say that on simultaneous exposure, fumonisin B 1 potentiated the toxic effects of OTA on renal ultrastructure.
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-012-1486-6