Photosensitizing and radiosensitizing effects of mitoxantrone: combined chemo-, photo-, and radiotherapy of DFW human melanoma cells

This study evaluated the effects of mitoxantrone (MX), an antitumor agent, as a sensitizer to both photodynamic and radiation therapy in DFW human melanoma cells. Cells were incubated with MX at different concentrations for 90 min and then exposed to non-coherent light at different fluence rates and...

Full description

Saved in:
Bibliographic Details
Published in:Lasers in medical science 2013-11, Vol.28 (6), p.1533-1539
Main Authors: Sazgarnia, Ameneh, Montazerabadi, Ali Reza, Bahreyni-Toosi, Mohammad Hossein, Ahmadi, Amirhossein
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
Chemotherapy
Clinical outcomes
Combined Modality Therapy
Dentistry
Humans
Lasers
Medicine
Medicine & Public Health
Melanoma
Melanoma - drug therapy
Melanoma - radiotherapy
Melanoma - therapy
Mitoxantrone - therapeutic use
Optical Devices
Optics
Original Article
Photochemotherapy
Photodynamic therapy
Photonics
Photosensitizing Agents - therapeutic use
Quantum Optics
Radiation therapy
Radiation-Sensitizing Agents - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluated the effects of mitoxantrone (MX), an antitumor agent, as a sensitizer to both photodynamic and radiation therapy in DFW human melanoma cells. Cells were incubated with MX at different concentrations for 90 min and then exposed to non-coherent light at different fluence rates and/or X-ray ionizing radiation at different dose rates. Combinatorial effects of this chemo-, photo-, and radiotherapy were also evaluated. MX had no significant effects on viability at moderate doses but had a strong cytotoxic effect on cancer cells when used as a photosensitizer. MX also acted as a potent radiosensitizer. We observed a dose-dependent effect on cell viability in cells exposed to MX in combination with phototherapy and radiotherapy. Strong synergistic effects were observed for combinations of two or more treatment methods, which, in some cases, induced complete cell death. Thus, a combination of ionizing radiation with MX-mediated photodynamic therapy could serve as a new method for cancer therapy with fewer adverse side effects.
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-013-1275-8