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Evidence for two mechanisms of depolarization associated with alpha sub(1)-adrenoceptor activation in the rat anococcygeus muscle
Membrane potential responses in the rat isolated anococcygeus to bath-applied noradrenaline and field stimulation have been investigated. The membrane potential at the maximum amplitude of the "fast" depolarization was similar to the equilibrium potential for the depolarization evoked by i...
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Published in: | British journal of pharmacology 1985-01, Vol.86 (3), p.711-721 |
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container_title | British journal of pharmacology |
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creator | Byrne, NG Large, WA |
description | Membrane potential responses in the rat isolated anococcygeus to bath-applied noradrenaline and field stimulation have been investigated. The membrane potential at the maximum amplitude of the "fast" depolarization was similar to the equilibrium potential for the depolarization evoked by ionophoretically applied noradrenaline and which was obtained by extrapolation from the relationship between amplitude of the ionophoretic response and membrane potential displacement in the partition chamber. These results suggest that the "fast" depolarization and the ionophoretic response are due to an increased membrane conductance, possibly to chloride. |
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The membrane potential at the maximum amplitude of the "fast" depolarization was similar to the equilibrium potential for the depolarization evoked by ionophoretically applied noradrenaline and which was obtained by extrapolation from the relationship between amplitude of the ionophoretic response and membrane potential displacement in the partition chamber. These results suggest that the "fast" depolarization and the ionophoretic response are due to an increased membrane conductance, possibly to chloride.</description><identifier>ISSN: 0007-1188</identifier><language>eng</language><subject>anococcygeus muscle ; depolarization ; rats</subject><ispartof>British journal of pharmacology, 1985-01, Vol.86 (3), p.711-721</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Byrne, NG</creatorcontrib><creatorcontrib>Large, WA</creatorcontrib><title>Evidence for two mechanisms of depolarization associated with alpha sub(1)-adrenoceptor activation in the rat anococcygeus muscle</title><title>British journal of pharmacology</title><description>Membrane potential responses in the rat isolated anococcygeus to bath-applied noradrenaline and field stimulation have been investigated. The membrane potential at the maximum amplitude of the "fast" depolarization was similar to the equilibrium potential for the depolarization evoked by ionophoretically applied noradrenaline and which was obtained by extrapolation from the relationship between amplitude of the ionophoretic response and membrane potential displacement in the partition chamber. These results suggest that the "fast" depolarization and the ionophoretic response are due to an increased membrane conductance, possibly to chloride.</description><subject>anococcygeus muscle</subject><subject>depolarization</subject><subject>rats</subject><issn>0007-1188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqNjD1Ow0AQRrcAKeHnDlMhKCztCkc2NQriAPTRMB7Hg9Y7zs5uIui4OZHgAFRf8d77Ltzae981IfT9yl2ZfXgf2q7brN339igDJ2IYNUM5KcxMEyax2UBHGHjRiFm-sIgmQDMlwcIDnKRMgHGZEKy-34eHBofMSYmXcr5CKnL8jSRBmRgyFsAzV6LPPVeDuRpFvnGXI0bj27-9dncv27fn12bJeqhsZTeLEceIibXaLrRt34anzeO_xR95uVSN</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Byrne, NG</creator><creator>Large, WA</creator><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19850101</creationdate><title>Evidence for two mechanisms of depolarization associated with alpha sub(1)-adrenoceptor activation in the rat anococcygeus muscle</title><author>Byrne, NG ; Large, WA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_144841953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>anococcygeus muscle</topic><topic>depolarization</topic><topic>rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byrne, NG</creatorcontrib><creatorcontrib>Large, WA</creatorcontrib><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byrne, NG</au><au>Large, WA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for two mechanisms of depolarization associated with alpha sub(1)-adrenoceptor activation in the rat anococcygeus muscle</atitle><jtitle>British journal of pharmacology</jtitle><date>1985-01-01</date><risdate>1985</risdate><volume>86</volume><issue>3</issue><spage>711</spage><epage>721</epage><pages>711-721</pages><issn>0007-1188</issn><abstract>Membrane potential responses in the rat isolated anococcygeus to bath-applied noradrenaline and field stimulation have been investigated. The membrane potential at the maximum amplitude of the "fast" depolarization was similar to the equilibrium potential for the depolarization evoked by ionophoretically applied noradrenaline and which was obtained by extrapolation from the relationship between amplitude of the ionophoretic response and membrane potential displacement in the partition chamber. These results suggest that the "fast" depolarization and the ionophoretic response are due to an increased membrane conductance, possibly to chloride.</abstract></addata></record> |
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ispartof | British journal of pharmacology, 1985-01, Vol.86 (3), p.711-721 |
issn | 0007-1188 |
language | eng |
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source | PubMed Central |
subjects | anococcygeus muscle depolarization rats |
title | Evidence for two mechanisms of depolarization associated with alpha sub(1)-adrenoceptor activation in the rat anococcygeus muscle |
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