Mechanical characteristics of swollen gellan gum hydrogels

ABSTRACT The behavior of swollen gellan gum hydrogels in terms of mechanical properties, weight loss, and cell growth inhibition of leachates is presented. Low‐acyl gellan gum (LAGG), high‐acyl gellan gum (HAGG), and a HAGG–LAGG blend were soaked in phosphate‐buffered saline (PBS) at pH 7.4 and 37°C...

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Bibliographic Details
Published in:Journal of applied polymer science 2013-12, Vol.130 (5), p.3374-3383
Main Authors: De Silva, D. Awanthi, Poole-Warren, Laura A., Martens, Penny J., in het Panhuis, Marc
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Blends
Exact sciences and technology
Gellan gum
Gels
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Hydrogels
Inhibition
Materials science
mechanical properties
Medical sciences
Natural polymers
Physicochemistry of polymers
Polymers
polysaccharides
Reproduction
Starch and polysaccharides
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swelling
Weight loss
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Summary:ABSTRACT The behavior of swollen gellan gum hydrogels in terms of mechanical properties, weight loss, and cell growth inhibition of leachates is presented. Low‐acyl gellan gum (LAGG), high‐acyl gellan gum (HAGG), and a HAGG–LAGG blend were soaked in phosphate‐buffered saline (PBS) at pH 7.4 and 37°C for up to 168 days. The gels exhibited their maximum mass loss and swelling after 28 days of immersion in PBS. LAGG gels exhibited lower value for mass loss and the chain‐release diffusion coefficient than gels consisting of HAGG and the HAGG–LAGG blend. The change in mechanical and rheological characteristics during soaking of the three hydrogels was attributed to mass loss, while LAGG hydrogels also showed evidence of effects because of cation exchange with the surrounding medium. The mechanical characteristics of the LAGG, HAGG, and blend hydrogels relative to each other did not change during swelling (although the magnitude changed). L929 fibroblasts growth inhibition tests showed that the leachate products of the three gels can be considered noncytotoxic, which is important for their future application in tissue engineering. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3374–3383, 2013
ISSN:0021-8995
1097-4628
DOI:10.1002/app.39583