Study on the preparation of genipin crosslinked chitosan microspheres of resveratrol and in vitro release

Resveratrol has attracted considerable public and scientific attention because of its beneficial effects on human health. In this study, resveratrol was encapsulated into chitosan microspheres for improving the stability and evaluating the ability of controlled release. Chitosan microspheres were pr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of polymer research 2013-07, Vol.20 (7), p.1-10, Article 175
Main Authors: Zhang, Yue, Yu, Yi-feng, Shi, Xian-xian, Zhao, Shu-chun, Chen, Ai-bing, Huang, Dao-wei, Niu, Dong-jie, Qin, Zhen
Format: Article
Language:English
Subjects:
Buffer solutions
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Controlled release
Crosslinking
Genipin
In vitro testing
Industrial Chemistry/Chemical Engineering
Microspheres
Original Paper
Polymer Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Resveratrol has attracted considerable public and scientific attention because of its beneficial effects on human health. In this study, resveratrol was encapsulated into chitosan microspheres for improving the stability and evaluating the ability of controlled release. Chitosan microspheres were prepared by using an emulsification-crosslinking method, and specifically, a natural extraction genipin was used as crosslinking agent for pursuit better physiological compatibility. Factors which influence on the shape and dispersity of microspheres were investigated to optimize the preparing process of resveratrol loaded genipin-chitosanmicrospheres. The optimum condition was obtained and the prepared resveratrol loaded genipin-chitosanmicrospheres were characterized by many technical instruments. Entrapment efficiency of resveratrol in genipin-chitosanmicrospheres is up to 87.6 %, and loading capacity is 7.9 %. The in vitro release rate in pH 3.6 buffer solution reached to 33.8 % within 72 h, but was lower in pH 7.4 buffer solution.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-013-0175-8