A Spectrum of p53 Mutations in Lung Cancer from Smokers: Review of Mutations Compiled in the IARC p53 Database

Lung cancer is one of the most common cancers worldwide, and tobacco is a major risk factor for developing lung cancer. Several chemicals in tobacco smoke are proven carcinogens, including benzo(a)pyrene, N-nitroso compounds, 4-aminobiphenyl, and vinyl chloride. Mutations of the p53 tumor suppressor...

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Bibliographic Details
Published in:Environmental health perspectives 1998-07, Vol.106 (7), p.385-385
Main Author: Hernandez-Boussard, Tina M
Format: Article
Language:English
Online Access:Get full text
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Summary:Lung cancer is one of the most common cancers worldwide, and tobacco is a major risk factor for developing lung cancer. Several chemicals in tobacco smoke are proven carcinogens, including benzo(a)pyrene, N-nitroso compounds, 4-aminobiphenyl, and vinyl chloride. Mutations of the p53 tumor suppressor gene occurs in most human cancers, including lung cancer. Data from the International Agency for Research on Cancer p53 mutation database were analyzed, confirming that G to T transversions are the predominant type of p53 mutations in lung cancer. In addition, lung cancer from smokers shows a different p53 mutation from lung cancer from nonsmokers. This pattern strengthens the association between smoking, exposure to polycyclic aromatic hydrocarbons such as benzo(a)pyrene, and lung cancer.
ISSN:0091-6765