Deoxyribonucleic acid polymorphism in the apolipoprotein A-I-C-III gene cluster: Association with hypertriglyceridemia

A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism i...

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Bibliographic Details
Published in:The Journal of clinical investigation 1985-01, Vol.76 (3), p.1090-1095
Main Authors: Rees, A, Stocks, J, Sharpe, C R, Vella, MA, Shoulders, C C, Katz, J, Jowett, N, Baralle, F E, Galton, D J
Format: Article
Language:English
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Summary:A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P < 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported.
ISSN:0021-9738