Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)‑SIRT1-Inhibitor IV

An enantioselective gram-scale synthesis of one of the most potent SIRT1-inhibitors has been accomplished by an unprecedented domino reaction sequence establishing the cyclohepta[b]indole core. This method was developed for application in natural product synthesis of a variety of indole alkaloids.

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Bibliographic Details
Published in:Organic letters 2013-11, Vol.15 (21), p.5472-5475
Main Authors: Gritsch, Philipp J, Stempel, Erik, Gaich, Tanja
Format: Article
Language:English
Subjects:
Biological Products
Catalysis
Indole Alkaloids - chemical synthesis
Indole Alkaloids - chemistry
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
Sirtuin 1 - analysis
Sirtuin 1 - chemical synthesis
Sirtuin 1 - chemistry
Stereoisomerism
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Summary:An enantioselective gram-scale synthesis of one of the most potent SIRT1-inhibitors has been accomplished by an unprecedented domino reaction sequence establishing the cyclohepta[b]indole core. This method was developed for application in natural product synthesis of a variety of indole alkaloids.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4026217