Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats

Highlights • Stimulation of the rostral ventrolateral medulla (RVLM) increased waking time. • RVLM stimulation decreased rapid eye movement sleep time. • RVLM stimulation increased the transitions between nonrapid eye movement (NREM) sleep and awake. • Awakening from NREM sleep occurred 1–2 s after...

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Bibliographic Details
Published in:Sleep medicine 2013-11, Vol.14 (11), p.1076-1084
Main Authors: Chen, C.Y, Kuo, Terry B.J, Hsieh, I.T, Yang, Cheryl C.H
Format: Article
Language:English
Subjects:
Animals
Arousal
Electric Stimulation - methods
Electrical stimulation
Electroencephalography
Electromyography
Heart Rate - physiology
Heart rate variability
Male
Medulla Oblongata - physiology
Neurology
Rats
Rats, Inbred WKY
Rostral ventrolateral medulla
Sleep
Sleep Medicine
Sleep, REM - physiology
Sympathetic nervous system
Sympathetic Nervous System - physiology
Telemetry - methods
Wakefulness - physiology
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Summary:Highlights • Stimulation of the rostral ventrolateral medulla (RVLM) increased waking time. • RVLM stimulation decreased rapid eye movement sleep time. • RVLM stimulation increased the transitions between nonrapid eye movement (NREM) sleep and awake. • Awakening from NREM sleep occurred 1–2 s after the initiation of stimulation.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2013.06.011