Peptide modification by introduction ofα-trifluoromethyl substituted amino acids

Methodology for the synthesis and incorporation ofα-trifluoromethyl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation ofα-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolytic stability and lipophilicity....

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Bibliographic Details
Published in:Amino acids 1995-06, Vol.8 (2), p.187-194
Main Authors: Sewald, N, Hollweck, W, Mütze, K, Schierlinger, C, Seymour, L C, Gaa, K, Burger, K, Koksch, B, Jakubke, H D
Format: Article
Language:English
Online Access:Get full text
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Summary:Methodology for the synthesis and incorporation ofα-trifluoromethyl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation ofα-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolytic stability and lipophilicity. Furthermore, it improves transport rates in vivo and permeability through certain body barriers.
ISSN:0939-4451
DOI:10.1007/BF00806491