A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)

Highlights • We use a model of focal epilepsy, S284L-TG, to evaluate prophylactic medication. • mRNA analysis reveals that KCC2 levels are decreased at the onset of epilepsy. • The Cl− homeostasis (i.e. EGABA ) is perturbed in S284L-TG neurons. • The excitatory synaptic responses are increased in S2...

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Bibliographic Details
Published in:Epilepsy research 2013-11, Vol.107 (1), p.127-137
Main Authors: Yamada, Junko, Zhu, Gang, Okada, Motohiro, Hirose, Shinichi, Yoshida, Shukuko, Shiba, Yuko, Migita, Keisuke, Mori, Fumiaki, Sugawara, Takayuki, Chen, Lei, Liu, Fang, Yoshida, Shuichi, Ueno, Shinya, Kaneko, Sunao
Format: Article
Language:English
Subjects:
ADNFLE
Animals
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Biological and medical sciences
Brain - drug effects
Brain - physiopathology
CHRNA4
Electroencephalography
Epilepsy, Frontal Lobe - drug therapy
Epilepsy, Frontal Lobe - genetics
Furosemide
Furosemide - pharmacology
Furosemide - therapeutic use
GABA
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
KCC2
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Prophylactic medication
Rats
Rats, Transgenic
Receptors, Nicotinic - genetics
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Summary:Highlights • We use a model of focal epilepsy, S284L-TG, to evaluate prophylactic medication. • mRNA analysis reveals that KCC2 levels are decreased at the onset of epilepsy. • The Cl− homeostasis (i.e. EGABA ) is perturbed in S284L-TG neurons. • The excitatory synaptic responses are increased in S284L-TG cortical neurons. • Early treatment with furosemide has a prophylactic effect on ADNFLE seizure.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2013.08.018