Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective

Highlights • Crosstalk of multiple pattern recognition receptors (PRRs) in respiratory syncytial virus (RSV) sensing is cell type-specific. • RSV entry route and compartmentalization determine PRR ligand accessibility. • RSV-derived components that bind to PRRs during natural RSV infection remain to...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2013-11, Vol.21 (11), p.568-574
Main Authors: Marr, Nico, Turvey, Stuart E, Grandvaux, Nathalie
Format: Article
Language:English
Subjects:
children
elderly
Human respiratory syncytial virus
Humans
Immunity, Innate
innate immunity
Internal Medicine
pathogen recognition receptors
pathogenesis
pathogens
receptors
Receptors, Pattern Recognition - immunology
Receptors, Pattern Recognition - metabolism
respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus Infections - pathology
Respiratory Syncytial Virus, Human - immunology
respiratory tract diseases
vaccine development
viruses
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Summary:Highlights • Crosstalk of multiple pattern recognition receptors (PRRs) in respiratory syncytial virus (RSV) sensing is cell type-specific. • RSV entry route and compartmentalization determine PRR ligand accessibility. • RSV-derived components that bind to PRRs during natural RSV infection remain to be identified. • Confirmation of PRR function in children is essential for vaccine design.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2013.08.006