Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studie...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-12, Vol.49 (95), p.11212-11214
Main Authors: Liu, Gerard Chun-Hao, Chen, Bryan Po-Wen, Ye, Nancy Ting-Juan, Wang, Chih-Hsien, Chen, Wenlung, Lee, Hsien-Ming, Chan, Sunney I, Huang, Joseph Jen-Tse
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amyloid - chemistry
Amyloid - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Fluoresceins - chemistry
Fluoresceins - metabolism
HEK293 Cells
Humans
Liposomes - chemistry
Molecular Sequence Data
Peptides - chemical synthesis
Peptides - chemistry
Protein Structure, Secondary
Protein Structure, Tertiary
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Summary:The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46762g