Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions

The flavoprotein (Fp) subunit of human mitochondrial succinate-ubiquinone reductase (SQR, complex II) has isoforms (type I, type II). Type II Fp is predominantly expressed in some cancer and fetal tissues and those tissues are often exposed to ischemia. The present study shows that complex II with t...

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Bibliographic Details
Published in:Mitochondrion 2013-11, Vol.13 (6), p.602-609
Main Authors: Sakai, Chika, Tomitsuka, Eriko, Miyagishi, Makoto, Harada, Shigeharu, Kita, Kiyoshi
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Base Sequence
DNA Primers
Electron Transport Complex II - genetics
Electron Transport Complex II - metabolism
Electron Transport Complex II - physiology
Humans
Hydrogen-Ion Concentration
Hypoxia - physiopathology
Malnutrition - physiopathology
Mitochondria - metabolism
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
RNA, Messenger - genetics
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Summary:The flavoprotein (Fp) subunit of human mitochondrial succinate-ubiquinone reductase (SQR, complex II) has isoforms (type I, type II). Type II Fp is predominantly expressed in some cancer and fetal tissues and those tissues are often exposed to ischemia. The present study shows that complex II with type II Fp has lower optimal pH than complex II with type I Fp, and type II Fp mRNA expression was induced by ischemia. The result suggests complex II with type II Fp may function in cells with low mitochondrial matrix pH caused by ischemia and its function is related to cellular adaptation to ischemia.
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2013.08.009