Pyrazole containing natural products: Synthetic preview and biological significance

• Published in: European journal of medicinal chemistry 2013-11, Vol.69, p.735-753
• Main Authors: Kumar, Vinod, Kaur, Kamalneet, Gupta, Girish Kumar, Sharma, Anil Kumar
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological Products - chemical synthesis; Biological Products - chemistry; Biological Products - pharmacology; Hypoglycemic Agents - chemical synthesis; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Isolation; Molecular Structure; Natural products; Pharmacological activities; Pyrazoles; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Pyrazoles - pharmacology
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2013.08.053

A large number of structurally diverse natural compounds containing azole nucleus constitute an important class of biologically active heterocycles that are gaining more attention in the field of medicinal chemistry. Among azoles, pyrazoles are rarely found in nature probably due to difficulty in the formation of N–N bond by living organisms. However, they exhibit numerous biological activities, including anti-diabetic, antiviral, anticancer, anti-inflammatory, antibacterial and antifungal activities. The present review is an attempt to understand the chemistry along with medicinal importance of pyrazole containing natural products reported till date which would certainly help the scientific community to bring further developments in the isolation and synthetic methodologies for pyrazole based novel bioactive compounds. Pyrazole containing natural products exhibit important biological properties. The present review describes the medicinal importance and different strategies used for isolation and total synthesis of pyrazole containing natural products. [Display omitted] •The review highlights the isolation, medicinal importance and synthetic routes towards natural pyrazoles.•Pyrazoles are rarely found natural chemical entities due to difficulty in formation of N–N bond by the living organisms.•Most of the existing natural pyrazoles displayed a wide spectrum of biological activities.