The effects of adjunctive parathyroid hormone injection on bisphosphonate-related osteonecrosis of the jaws: an animal study

Abstract Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a serious and challenging complication of chronic BP uptake in patients with osteoporosis who require management of skeletal-related events. The efficiency of adjunctive parathyroid hormone (PTH) injection was evaluated after c...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2013-11, Vol.42 (11), p.1475-1480
Main Authors: Dayisoylu, E.H, Şenel, F.Ç, Üngör, C, Tosun, E, Çankaya, M, Ersöz, S, Taskesen, F
Format: Article
Language:English
Subjects:
animal model
Animals
Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy
Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology
bisphosphonate-related osteonecrosis of the jaw
Bone Density Conservation Agents - adverse effects
Dentistry
Diphosphonates - adverse effects
Disease Models, Animal
Female
Imidazoles - adverse effects
Jaw Diseases - drug therapy
Mandible - cytology
Mandible - drug effects
Osteogenesis - drug effects
Osteoporosis - chemically induced
parathyroid hormone
Parathyroid Hormone - therapeutic use
Rats
Rats, Sprague-Dawley
Surgery
teriparatide
Tooth Extraction
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Summary:Abstract Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a serious and challenging complication of chronic BP uptake in patients with osteoporosis who require management of skeletal-related events. The efficiency of adjunctive parathyroid hormone (PTH) injection was evaluated after chronic BP administration that was followed by tooth extraction. BRONJ was not observed in any of the subjects in the control groups, while BRONJ was observed in 66% and 22% of the subjects in the tooth extraction group and the tooth extraction with PTH injection group, respectively. In addition the presence and severity of inflammation was lower in the PTH injected group than in the tooth extraction group, but the difference was not statistically significant ( P > 0.01). In conclusion, the administration of 30 μg/kg/day PTH during a period of 8 weeks had positive effects on the resolution of BRONJ, but further studies are required to verify the effectiveness of PTH in the treatment of BRONJ.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2013.05.001