No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration

Abstract Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100 mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not signifi...

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Bibliographic Details
Published in:Psychiatry research 2013-12, Vol.210 (2), p.662-664
Main Authors: Kellner, Michael, Salzwedel, Cornelie, Wortmann, Viola, Urbanowicz, Tatiana, Boelmans, Kai, Yassouridis, Alexander, Stalla, Günter K, Wiedemann, Klaus
Format: Article
Language:English
Subjects:
Administration, Intravenous
Adult
Behavior - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain - physiology
Cerebrospinal fluid (CSF)
Corticotropin-releasing hormone (CRH)
Corticotropin-Releasing Hormone - cerebrospinal fluid
Cortisol
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Hydrocortisone - administration & dosage
Male
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
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Summary:Abstract Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100 mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not significantly suppressed by cortisol within 3 h. The origin and regulation of CSF CRH need further research.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2013.07.003