Quercetin glucosides promote ischemia-induced angiogenesis, but do not promote tumor growth

Dietary flavonoid intake shows a significant inverse association with mortality from coronary heart disease, incidence of myocardial infarction and stroke. Quercetin is one of the most common flavonoids in our diet and has several favorable biological activities. Quercetin glucosides, which are enzy...

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Bibliographic Details
Published in:Life sciences (1973) 2013-11, Vol.93 (22), p.814-819
Main Authors: Sumi, Makoto, Tateishi, Norifumi, Shibata, Hiroshi, Ohki, Takao, Sata, Masataka
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inducing Agents - chemistry
Angiogenesis Inducing Agents - pharmacology
Animals
Antioxidants - metabolism
bioavailability
blood flow
Capillaries - physiopathology
carboxymethylcellulose
Collateral
coronary disease
Cytokines - blood
diet
Disease Models, Animal
Flavonoids
glucosides
Glucosides - chemistry
Glucosides - pharmacology
Hindlimb - blood supply
Hindlimb - drug effects
image analysis
Ischemia - drug therapy
Ischemia - physiopathology
isoquercitrin
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Mutant Strains
mortality
muscles
myocardial infarction
Neoplasms - chemically induced
Neovascularization, Pathologic - chemically induced
Neovascularization, Physiologic - drug effects
Nitric Oxide Synthase Type III - genetics
Nitric Oxide Synthase Type III - metabolism
quercetin
Quercetin - analogs & derivatives
Quercetin - chemistry
Quercetin glucosides
stroke
water solubility
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Summary:Dietary flavonoid intake shows a significant inverse association with mortality from coronary heart disease, incidence of myocardial infarction and stroke. Quercetin is one of the most common flavonoids in our diet and has several favorable biological activities. Quercetin glucosides, which are enzymatically trans-glycosylated isoquercitrin, have high water-solubility and bioavailability compared with quercetin. Here, we investigated the effects of quercetin glucosides on collateral development in a murine hindlimb ischemia model. We induced hindlimb ischemia in 24- to 32-week-old male C3H/HeJ mice by resecting the right femoral artery. Then, 0.5% carboxymethyl cellulose (control) or quercetin glucosides (100mg/kg/day) were administered daily by gavage. Blood flow was monitored weekly by laser Doppler imaging. Recovery of blood flow to the ischemic leg was significantly enhanced by quercetin glucosides (blood flow ratio at 4weeks: control, 0.57±0.11; quercetin glucosides, 0.95±0.10, p
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2013.09.005