A case of possible HIV prophylaxis-induced anxiety and obsessive–compulsive disorder

Abstract There is considerable literature on the neuropsychiatric effects of antiretrovirals. This is the first case, to our knowledge, of new-onset obsessive–compulsive symptoms correlated with emtricitabine/tenofovir, a commonly prescribed HIV prophylaxis combination. We describe the case of a wom...

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Bibliographic Details
Published in:General hospital psychiatry 2013-11, Vol.35 (6), p.679.e11-679.e12
Main Authors: Hauptman, Aaron, M.D, Carchedi, Lisa, M.D
Format: Article
Language:English
Subjects:
ADE
Adenine - adverse effects
Adenine - analogs & derivatives
Adult
Adverse event
Anti-HIV Agents - adverse effects
Antiretroviral
Anxiety
Anxiety Disorders - chemically induced
Deoxycytidine - adverse effects
Deoxycytidine - analogs & derivatives
Emtricitabine
Female
HIV
HIV Infections - prevention & control
Humans
Neuropsychiatry
Obsessive-Compulsive Disorder - chemically induced
Obsessive–Compulsive disorder
Organophosphonates - adverse effects
Psychiatry
Side effect
Tenofovir
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Summary:Abstract There is considerable literature on the neuropsychiatric effects of antiretrovirals. This is the first case, to our knowledge, of new-onset obsessive–compulsive symptoms correlated with emtricitabine/tenofovir, a commonly prescribed HIV prophylaxis combination. We describe the case of a woman, who developed upsetting obsessive thoughts following initiation of this pharmacotherapy and include discussion of relevant literature.
ISSN:0163-8343
1873-7714
DOI:10.1016/j.genhosppsych.2013.03.010