An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital

• Published in: Intensive care medicine 2013-12, Vol.39 (12), p.2161-2170
• Main Authors: Hernu, R., Wallet, F., Thiollière, F., Martin, O., Richard, J. C., Schmitt, Z., Wallon, G., Delannoy, B., Rimmelé, T., Démaret, C., Magnin, C., Vallin, H., Lepape, A., Baboi, L., Argaud, L., Piriou, V., Allaouchiche, B., Aubrun, F., Bastien, O., Lehot, J. J., Ayzac, L., Guérin, C.
• Format: Article
• Language: English
• Subjects: Acute Lung Injury - classification; Acute Lung Injury - epidemiology; Acute Lung Injury - therapy; Acute respiratory distress syndrome; Aged; Analysis; Anesthesiology; Consensus Development Conferences as Topic; Critical Care Medicine; Emergency Medicine; Europe; Female; France; Germany; Health aspects; Hospital Mortality; Hospitals, University; Humans; Incidence; Intensive; Intensive care; Intensive Care Units; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Middle Aged; Mortality; Observational studies; Original; Pain Medicine; Patients; Pediatrics; Pneumology/Respiratory System; Positive-Pressure Respiration; Prevalence; Proportional Hazards Models; Prospective Studies; Respiration, Artificial; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - classification; Respiratory Distress Syndrome, Adult - epidemiology; Respiratory Distress Syndrome, Adult - therapy; United Kingdom; United States; Ventilators
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-013-3122-6

Purpose The Berlin definition for acute respiratory distress syndrome (ARDS) is a new proposal for changing the American-European consensus definition but has not been assessed prospectively as yet. In the present study, we aimed to determine (1) the prevalence and incidence of ARDS with both definitions, and (2) the initial characteristics of patients with ARDS and 28-day mortality with the Berlin definition. Methods We performed a 6-month prospective observational study in the ten adult ICUs affiliated to the Public University Hospital in Lyon, France, from March to September 2012. Patients under invasive or noninvasive mechanical ventilation, with PaO 2 /FiO 2   0.05 between the three groups). The incidence of ARDS amounted to 32 per 100,000 population per year, with values for mild, moderate, and severe ARDS of 5.6, 16.3, and 10 per 100,000 population per year, respectively ( P