Effects of short-term intensive glycemic control on insulin, glucagon, and glucagon-like peptide-1 secretion in patients with Type 2 diabetes

Background: Short-term intensive insulin therapy (IIT) in patients with Type 2 diabetes mellitus (T2DM) has beneficial effects on insulin secretion. However, IIT effect on glucagon and glucagon-like peptide-1 (GLP-1) secretion is unknown. Aim: We evaluated short-term intensive glycemic control effec...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2013-10, Vol.36 (9), p.734-738
Main Authors: Shimodaira, M., Muroya, Y., Kumagai, N., Tsuzawa, K., Honda, K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood Glucose - metabolism
C-Peptide - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Endocrinology
Female
Glucagon - blood
Glucagon - metabolism
Glucagon-Like Peptide 1 - blood
Glucagon-Like Peptide 1 - metabolism
Humans
Insulin - blood
Insulin - metabolism
Insulin - therapeutic use
Insulin Secretion
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Short-term intensive insulin therapy (IIT) in patients with Type 2 diabetes mellitus (T2DM) has beneficial effects on insulin secretion. However, IIT effect on glucagon and glucagon-like peptide-1 (GLP-1) secretion is unknown. Aim: We evaluated short-term intensive glycemic control effects on insulin, glucagon, and GLP-1 secretory dynamics in T2DM. Materials and methods: Twenty-six patients with T2DM were hospitalized and treated with IIT for 10–14 days. A meal tolerance test was performed before and after IIT and the differences in serum immunoreactive insulin (IRI) and C-peptide immunoreactivity (CPR) as well as plasma glucagon and active GLP-1 levels were evaluated. Results: Glycoalbumin levels decreased significantly from 23.0% before to 19.6% after IIT ( p
ISSN:0391-4097
1720-8386
DOI:10.3275/8934