Role of Endothelial Cell Metabolism in Vessel Sprouting

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and proliferating stalk cells that elongate the sprout. Past studies have identified genetic signals that control...

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Bibliographic Details
Published in:Cell metabolism 2013-11, Vol.18 (5), p.634-647
Main Authors: De Bock, Katrien, Georgiadou, Maria, Carmeliet, Peter
Format: Article
Language:English
Subjects:
Cell Respiration
Endothelial Cells - metabolism
Feedback, Physiological
Humans
Metabolic Networks and Pathways
Mitochondria - metabolism
Neovascularization, Physiologic
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Summary:Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and proliferating stalk cells that elongate the sprout. Past studies have identified genetic signals that control vascular branching. Prominent are VEGF, activating tip cells, and Notch, which stimulates stalk cells. After the branch is formed and perfused, ECs become quiescent phalanx cells. Now, emerging evidence has accumulated indicating that ECs not only adapt their metabolism when switching from quiescence to sprouting but also that metabolism regulates vascular sprouting in parallel to the control by genetic signals.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2013.08.001