Systems approaches to studying the immune response in tuberculosis

Highlights • Blood transcriptional profiling in human TB has been reproducible in many studies. • Transcriptional profiling has highlighted the importance of type I interferons in TB. • Transcriptional profiles provide biomarkers for diagnosis and treatment monitoring.

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Bibliographic Details
Published in:Current opinion in immunology 2013-10, Vol.25 (5), p.579-587
Main Authors: Berry, Matthew Paul Reddoch, Blankley, Simon, Graham, Christine Marian, Bloom, Chloe I, O’Garra, Anne
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Host-Pathogen Interactions
Humans
Interferon Type I - immunology
Lymphocytes - immunology
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - isolation & purification
Systems Biology - methods
Tuberculosis - immunology
Tuberculosis - microbiology
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Description
Summary:Highlights • Blood transcriptional profiling in human TB has been reproducible in many studies. • Transcriptional profiling has highlighted the importance of type I interferons in TB. • Transcriptional profiles provide biomarkers for diagnosis and treatment monitoring.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2013.08.003